Welcome to the Forum
Methods In this study, we evaluated a number of immuno-histochemical outcomes to test the hypothesis that injured rat sciatic nerves accommodate strains of up to 20%, a deformation magnitude that exceeds oft-quoted thresholds for nerve damage. We also assessed the possibility of integrating tension with conduit-based approaches for nerve repair. Results and Discussion: There were no deficits in axonal, basal laminar, or extracellular matrix morphology with tension, though proximal and distal stumps of nerves in all experimental groups displayed abnormal morphology in proximity to the site of injury. Axons of stretched nerves successfully grew through guidance conduits into the distal stump within 6 weeks of repair, thus demonstrating the feasibility Spain phone number list of combining tension- and conduit-based regenerative strategies. Are a debilitating clinical challenge, resulting in motor dysfunction, sensory loss, and chronic pain. For transected nerves, end-to-end repairs lead to superior clinical outcomes compared to graft-based repairs (Millesi, 1986; Garg et al., 2021). However, excess tension at the repair site can result in nerve damage and catastrophic repair failure (Maeda et al., 1999; Sunderland et al., 2004). Given this concern, surgeons typically use a graft to repair larger. Autologous grafts (autografts) are the current gold standard for repairing such gaps, but are limited by donor site morbidity, neuroma, geometric mismatch of the graft with proximal and distal nerve stumps, and limitations on the length and viability of grafts that can be harvested (Schmidt and Leach, 2003; Meek et al., 2005; Selim et al., 2022). Furthermore, autograft efficacy is markedly decreased for gaps >3 cm (Selim et al., 2022). Most alternative strategies for treating severe nerve injury involve the engineering of synthetic, biological, or hybrid conduits or grafts of increasing elegance and complexity.
Like